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Efficacy of bupropion and the selective serotonin reuptake inhibitors in the treatment of major depressive disorder with high levels of anxiety (anxious depression): a pooled analysis of 10 studies".
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Secondary cessation outcome measures will include continuous smoking abstinence during the last four weeks of the trial (Days 29-56) and 7-day point prevalence abstinence at the end of the 8-week trial (Days 49-56).
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About 52% of the EMSAM-treated patients, as well as about 52% of the placebo-treated patients, had discontinued treatment by week 12 of the double-blind phase.
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However, because its long-term use at high dosages may lead to motor complications that can be difficult to manage, many physicians switch to dopamine-receptor agonists (see next column).
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Patients should be advised not to use carbamazepine or oxcarbazepine while on EMSAM therapy.
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